Research Articles
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Seungmee Park , Nathaniel Noblett, Lauren Pitts, Antonio Colavita, Ann M Wehman, Yishi Jin, Andrew D Chisholm (2024) Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology. Current Biology DOI: 10.1016/j.cub.2024.09.018 .
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Byrd DT, Han ZC, Piggott CA, Jin Y. (2024) PACS-1 variant protein is aberrantly localized in C. elegans model of PACS1/PACS2 syndromes. . Genetics.
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Sun Y, Jin Y (2023) An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration . Proc Natl Acad Sci U S A . .
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Mizumoto K, Jin Y, Bessereau JL. (2023) Synaptogenesis: unmasking molecular mechanisms using Caenorhabditis elegans . Genetics .
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Blazie SM, Takayanagi-Kiya S, McCulloch KA, Jin Y. (2021) Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity. Elife. 10:e68336. doi: 10.7554/eLife.68336. .
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Byrd DT, Jin Y (2021) Wired for insight-recent advances in Caenorhabditis elegans neural circuits . Curr Opin Neurobiol. 69:159-169. doi: 10.1016/j.conb.2021.02.009. .
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Christopher A Piggott, Zilu Wu, Stephen Nurrish, Suhong Xu, Joshua M Kaplan, Andrew D Chisholm, Yishi Jin (2021) Caenorhabditis elegans Junctophilin has tissue-specific functions and regulates neurotransmission with extended-synaptotagmin. Genetics.
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Li Y, Ritchie EM, Steinke CL, Qi C, Chen L, Zheng B, Jin Y. (2021) Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength . eLife.
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McCulloch, K.A., Zhou, K., and Jin, Y. (2020) Neuronal transcriptome analyses reveal novel neuropeptide modulators of excitation and inhibition imbalance in C. elegans. . PLoSOne. e0233991.
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Cherra SJ 3rd, Goncharov A, Boassa D, Ellisman M, Jin Y. (2020) C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density. . J. Neurogenetics.
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Tang, N. H., Kim, K., Xu, S., Blazie, S. M. Yee, B. A., Yeo, G. W., Jin, Y., and Chisholm A. D (2020) The mRNA decay factor CAR-1 regulates axon regeneration via mitochondrial calcium dynamics.. Current Biology.
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Andrusiak MG, Sharifnia P, Lyu X, Wang Z, Dickey AM, Wu Z, Chisholm AD, Jin Y. (2019) Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules. Neuron. 2019 Oct 23;104(2):290-304.e8. doi: 10.1016/j..
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Kushibiki Y, Suzuki T, Jin Y, Taru H. (2019) 1. RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel in Caenorhabditis elegans.. J Neurosci. 2019 Oct 30;39(44):8617-8631. doi: 10.1523/JNEUROSCI.0506-19.2019. .
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Malinow RA, Ying P, Koorman T, Boxem M, Jin Y, Kim KW. (2019) Functional Dissection of C. elegans bZip-Protein CEBP-1 Reveals Novel Structural Motifs Required for Axon Regeneration and Nuclear Import.. Front Cell Neurosci. 2019 Jul 31;13:348. doi: 10.3389/fncel.2019.00348. eCollection 2019..
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Cenik ES, Meng X, Tang NH, Hall RN, Arribere JA, Cenik C, Jin Y, Fire A. (2019) Maternal Ribosomes Are Sufficient for Tissue Diversification during Embryonic Development in C. elegans.. Dev Cell. 48:811-826..
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Noblett, N., Wu, Z., Ding, Z. H., Park, S., Roenspies, T.,, Flibotte, S.,, Chisholm, A.D., Jin, Y., Colavita, A.,2. (2019) DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.. J. Cell Biol. 218(1):125-133. doi: 10.1083/jcb.201804207.
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Kim, K.W., Tang, N. H., Piggott, C., Andrusiak, M.G., Park, S., Zhu, M., Kurup, N., Cherra, III, S. J., Wu, Z., Chisholm, A.D., Jin, Y. (2018) Expanded genetic screening in C. elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration. eLife. pii: e39756. doi: 10.7554/eLife.39756..
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Noma K, Jin Y. (2018) Rapid Integration of Multi-copy Transgenes Using Optogenetic Mutagenesis in Caenorhabditis elegans.. G3, 8:2091-2097. .
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Chen M, Geoffroy CG, Meves JM, Narang A, Li Y, Nguyen MT, Khai VS, Kong X, Steinke CL, Carolino KI, Elzière L, Goldberg MP, Jin Y, Zheng B. (2018) Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep. 2018 Mar 27;22(13):3587-3597. doi: 10.1016/j.celrep.2018.02.102..
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Kurup N, Li Y, Goncharov A, Jin Y. (2018) Intermediate filament accumulation can stabilize microtubules in Caenorhabditis elegans motor neurons.. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3114-3119. .
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Kim, K., Tang, N-H., Andrusiak, M., Wu, Z., Chisholm, A.D, and Jin, Y. (2018) A Neuronal PiRNA pathway inhibits axon regeneration in C. elegans. Neuron. 2018 Feb 7;97(3):511-519.e6. doi: 10.1016/j.neuron.2018.01.014..
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Noma, K., Goncharov, A., Ellisman, M., and Jin, Y. (2017) Microtubule-dependent ribosome localization in C. elegans neurons. eLife. 6. pii: e26376. doi: 10.7554/eLife.26376..
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Zhou, K., Cherra, S. J., Goncharov, A. and Jin, Y. (2017) Asynchronous cholinergic drive breaks excitation-inhibition balance via a neuronal Ca2+ sensor protein. Cell Reports. 19(6):1117-1129. doi: 10.1016/j.celrep.2017.04.043. PMID 28494862.
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McCulloch, K., Qi, Y. B., Takayagani-Kiya, S., and Jin, Y*, Cherra, S. J. (2017) Novel mutations in synaptic transmission genes suppress neuronal hyperexcitation in C. elegans. G3. 7(7):2055-2063. doi: 10.1534/g3.117.042598. PMID 28468816.
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Sharifnia P, Kim, K. W. Wu, Z., and Jin, Y. (2017) Distinct cis elements in 3’ UTR of C. elegans cebp-1 mRNA mediate its regulation in neuronal development. Devel. Biol. 429:240-248.
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Kurup, N., Yan, D., Kono, K., and Jin, Y. (2017) Differential regulation of polarized synaptic vesicle trafficking and synapse stability in C. elegans neural circuit rewiring. PLoS Genetics. 13(6):e1006844. doi: 10.1371/journal.pgen.1006844. PMID:28636662; PMCID:PMC5500376.
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Knowlton, W. M., Hubert, T., Wu, Z., Chisholm, A. D, and Jin, Y. (2017) A Select Subset of Electron Transport Chain Genes Associated with Optic Atrophy Link Mitochondria to Axon Regeneration in Caenorhabditis elegans.. Front. Neurosci. 11:263. doi: 10.3389/fnins.2017.00263. eCollection 2017. PMID:28539870; PMCID: PMC5423972.
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Meng, J., Ma, X., Tao, H., Jin, X., Witvliet, D., Zhu, M., Dong, M., Zhen, M., Jin, Y., and Qi, Y. B. (2017) The Myrf family of ER-bound transcription factors cooperatively control synaptic rewiring in C. elegans via cleavage-dependent nuclear translocation. Dev Cell 41:180-194, PMID28441531.
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Chen, F., Chisholm, A. D., and Jin, Y. (2017) Tissue-specific regulation of alternative polyadenylation represses expression of neuronal ankyrin isoform in C. elegans epidermal development. Development 144: 698-707. PMC 5312038.
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Kim, K.W.*, Thakur, N., Piggott, C. A., Omi, S., Polanowska, J., Jin, Y.*, and Pujol, N*. (2016) Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for C. elegans development. BMC Biology, 14(1):104. PMID: 27927209, PMCID: PMC5141650.
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Chisholm, A. D., Hutter, H., Jin, Y., and Wadsworth, W.G. (2016) The genetics of axon guidance and axon regeneration in Caenorabditis elegans. In Wormbook, Genetics, 204(3):849-882..
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Takayanagi-Kiya, S., Zhou, K., and Jin, Y. (2016) Release-dependent feedback inhibition by a presynaptically localized ligand gated anion channel. eLife, Oct 26;5. pii: e21734. doi: 10.7554/eLife.21734. PMID: 27782882; PMCID:PMC5102579.
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Meng, L., Zhang, A., Jin, Y., and Yan, D. (2016) Regulation of neuronal axon specification by glia-neuron gap junctions in C. elegans.. eLife, Oct 21;5. pii: e19510. doi: 10.7554/eLife.19510..
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Chen, M., Geoffroy, C. G., Wong, H. N., Nguyen, M. T., Holzman, L. B., Jin, Y., and Zheng, B. (2016) Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.. Scientific Reports. 6:31482. doi: 10.1038/srep31482..
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Takayanagi-Kiya S., and Jin, Y. (2016) Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. G3. pii: g3.116.028928. doi: 10.1534/g3.116.028928. PMID:27185401; PMCID:PMC4938669.
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Chen, L., Liu, Z., Zhou, B., Wei, C., Zhou, Y., Rosenfeld, M. G., Fu, X. D., Chisholm, A. D., and Jin, Y. (2016) CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of Syntaxins.. eLife. Jun 2;5. pii: e16072. doi: 10.7554/eLife.16072..
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Xu, S., Wang, Z., Kim, K. W., Jin, Y. and Chisholm, A. D. (2016) Targeted mutagenesis of duplicated genes in Caenorhabditis elegans using CRISPR-Cas9.. J Genet Genomics. 43(2):103-6. doi: 10.1016/j.jgg.2015.11.004. PMID:26924693..
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Cherra, S. J., and Jin, Y. (2016) A Two-Immunoglobulin-Domain Transmembrane Protein Mediates an Epidermal-Neuronal Interaction to Maintain Synapse Density. Neuron, 89:325-36. PMID:26777275. PMCID: PMC4871750.
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Holland, S.M., Collura, K. M., Ketschek A., Noma, K., Ferguson, T. A., Jin, Y., Gallo, G., and Thomas, G. M. (2016) Palmitoylation Controls DLK Localization, Interactions and Activity to Ensure Effective Axonal Injury Signaling.. Proc Natl Acad Sci. 113:763-8. PMID: 26719418; PMCID:PMC4725513.
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Noma, K., and Jin, Y. (2015) Optogenetic mutagenesis in Caenorhabditis elegans.. Nature Communications, Dec 3;6:8868. PMID:26632265; PMCID:PMC4686824.
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Fei Chen, Yu Zhou, Yingchuan B. Qi, Vishal Khivansara, Hairi Li, Sang Young Chun, John K. Kim, Xiang-Dong Fu, and Yishi Jin (2015) Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development. Genes Dev. 2377–2390. doi: 10.1101/gad.266650.115.
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Chen, F., Zhou, Y., Qi, Y. B. Khivansara, V., Li, H., Chun, S. Y., Kim, J. K., Fu, X., and Jin, Y. (2015) Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development. Genes & Development, 29:2377-90. PMID:26588990; PMCID:PMC4691892. .
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Chen, L., Chuang, M., Koorman, T., Boxem, M., Jin, Y.*, and Chisholm, A.D*. (2015) Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase. eLife Sep 4;4. doi: 10.7554/eLife.08695. PMID:26339988..
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Meng, L., Mulcahy, B., Cook, S.J., Neubauer, M., Wan, A., Jin, Y., and Yan, D. (2015) The cell death pathway regulates synapse elimination through cleavage of gelsolin in Caenorhabditis elegans neurons.. Cell Reports. 11(11):1737-48. PMID:26074078; PMCID:PMC4481169.
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Naina Kurup, Dong Yan, Alexandr Goncharov, and Yishi Jin (2015) Dynamic microtubules drive circuit rewiring in the absence of neurite remodeling. Curr Biol. 25(12):1594-605. PMID:26051896; PMCID:PMC4470761.
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Xu, Y., Taru, H., Jin, Y., and Quinn, C. C. (2015) SYD-1C, UNC-40(DCC) and SAX-3(Robo) function interdependently to promote axon guidance by regulating the MIG-2 GTPase.. PLoS Genet. 11(4):e1005185..
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Chuang M., Goncharov, A., Wang, S., Oegema, K., Jin, Y. and Chisholm, A. D. (2014) The microtubule minus end binding protein Patronin/PTRN-1 is required for axon regeneration in C. elegans.. Cell Reports, 9(3):874-83. PMID:25437544; PMCID:PMC4250830.
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Noma, K., Goncharov, A., and Jin, Y. (2014) Systematic Analyses of rpm-1 Suppressors Reveal Roles for the DGCR14 ortholog ESS-2 in mRNA Splicing in Caenorhabditis elegans.. Genetics 198(3):1101-15..
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Hubert, T., Wu, Z., Chisholm, A. D., and Jin, Y. (2014) S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in C. elegans.. J. Neurosci. 34(3):758-63..
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Kittelmann, M., Hegermann, J., Goncharov, A., Taru, H., Ellisman, M. H., Richmond, J. E., Jin, Y., and Eimer, S. (2013) Liprin-α/SYD-2 determines the size of dense projections in presynaptic active zones in C. elegans.. J. Cell Biol. 203(5):849-63..
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Zhou, K., Stawicki, T., Goncharov, A., and Jin, Y. (2013) Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics.. eLife Nov 12;2:e01180..
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Wang, Z., Hou, Y., Guo, X., van der Voet, M., Boxem, M., Dixon, J. E., and Jin, Y. (2013) The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons.. Neuron, 79(5):903-16..
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Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm AD, Jin Y. (2013) The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron. 903-16. doi: 10.1016/j.neuron.2013.06.035..
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Lin, J. Y., Sann, S. B., Zhou, K., Nabavi, S., Proulx, C., Malinow, R., Jin, Y., and Tsien, R. Y. (2013) Lin, J. Y., Sann, S. B., Zhou, K., Nabavi, S., Proulx, C., Malinow, R., Jin, Y., and Tsien, R. Y.. Neuron 79:241-53..
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Caylor, R. C., Jin, Y., and Ackley B. D. (2013) The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.. Neural Development, 8:10. DOI: 10.1186/1749-8104-8-10..
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Stawicki, T. M., Takayanagi-Kiya, S. Zhou, K., and Jin, Y. (2013) Neuropeptides Function to Dampen Severity of Epileptic-Like Convulsions in C. elegans.. PLoS Genetics, (5):e1003472..
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Qi, Y. B., Po, M., McEachern, P., Kawano, T., Jorgensen, E.M., Zhen, M., and Jin, Y. (2013) Dendritic hyperactivation of B-type motor neurons results in aberrant synchrony of the C. elegans motor circuit.. J. Neurosci, 33(12): 5319-5325..
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Yan, D., and Jin, Y. (2012) Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform. Neuron, 76:534-48..
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Sann, S. B., Crane, M. M., Lu, H., and Jin, Y. (2012) Rabx-5 regulates RAB-5 early endosomal compartments and synaptic vesicles in C. elegans.. PLoS One 7(6): e37930..
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Qi, B. Y., Garren, E., Shu, X., Tsien, R. Y., and Jin, Y. (2012) Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG. Proc Natl Acad Sci. 109:7499-504..
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Stawicki, T.M., Zhou, K., Yochem J., Chen, L., and Jin, Y. (2011) TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis. Current Biology 21(10):883-888..
Reviews
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Piggott CA, Jin Y. (2021) Junctophilins: Key Membrane Tethers in Muscles and Neurons. . Front Mol Neurosci. 14:709390. doi: 10.3389/fnmol.2021.709390..
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Treinin M, Jin Y (2020) Cholinergic transmission in C. elegans: Functions, diversity, and maturation of ACh-activated ion channels . J. Neurochem.
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Jin Y, Zheng B. (2019) Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management.. Annu Rev Cell Dev Biol. 2019 Oct 6;35:501-521. .
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Tang NH, Jin Y. (2018) Shaping neurodevelopment: distinct contributions of cytoskeletal proteins.. Curr Opin Neurobiol. 2018 Mar 22;51:111-118..
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Jin, Y. and Qi, Y. B. (2017) Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans.. Curr Opin Neurobiol. 48:97-105. doi: 10.1016/j.conb.2017.11.005..
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He, Z., and Jin, Y. (2016) Intrinsic Control of Axon Regeneration: Mechanisms and Applications. Neuron, 90:437-51. PMID 27151637.
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Andrusiak A., and Jin, Y. (2016) Context specificity of stress MAP Kinase signaling: the story as told by C. elegans. J. Biol. Chem., 291:7796-804.
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Noma, K., and Jin, Y. (2016) Optogenetic random mutagenesis using Histone-miniSOG in C. elegans. J Vis Exp. 2016 Nov 14;(117). doi: 10.3791/54810. PMID:27911392.
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Sharifnia, P., and Jin, Y. (2015) Regulatory roles of RNA binding proteins in the nervous system of C. elegans. Front Mol Neurosci. 7:100. doi: 10.3389/fnmol.2014.00100.
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Cherra, S., and Jin, Y. (2015) Adances in synapse formation: Forging connections in the worm. WIRES Developmental Biology. 4(2):85-97. doi: 10.1002/wdev.165.
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Kim, K. W., and Jin, Y. (2015) Neuronal responses to stress and injury in C. elegans. FEBS Lett. 589(14):1644-1652.
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Kurup, N., and Jin, Y. (2015) Neuronal circuit rewiring: insights from DD synapse remodeling. Worm, Dec 10;5(1):e1129486.
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Wang, Z., and Jin, Y. (2010) Genetic analysis of axon regeneration. Curr. Opin. Neurobiol. 21: 1-8.
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Sann, S., Wang, Z. P., Brown, H., and Jin, Y. (2009) Roles of endosomal trafficking in neurite outgrowth and guidance. Trends Cell Biol. 19: 317-324.
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Jin, Y. and Garner, C. C. (2008) Molecular mechanisms of presynaptic differentiation. Annual Review of Cell and Developmental Biology 24: 237-262.
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Jin, Y. (2005) Synaptogenesis. Chapter in online “Wormbook†(ed. M. Chalfie).
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Jin, Y. (2002) Synaptogenesis: insights from worm and fly. Current Opinion in Neurobiology. 12:71-79.
Representative Early Publications
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Jospin, M., Stawicki, T., Qi, Y.B., Boulin, T., Horvitz, H. R., Bessereau, J. L., Jorgensen, E., and Jin, Y. (2009) A Neuronal Acetylcholine Receptor Regulates the Balance of Muscle Excitation and Inhibition in Caenorhabditis elegans locomotion. PLoS Biol. Dec;7(12):e1000265..
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Yan, D., Wu, Z., Chisholm, A. D., and Jin, Y. (2009) The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell 138:1005-1018..
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Nakata, K., Abrams, B., Grill, B., Goncharov, A., Huang, X., Chisholm, A. D., and Jin, Y. (2005) Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell 120:407-420..
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Yanik, M. F., Cinar, H., Cinar, H. N., Chisholm, A. D., Jin, Y., and Ben-Yakar, A. (2004) Neurosurgery: Functional regeneration after laser axotomy. Nature 432:822..
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Zhen, M., Huang, X., Bamber, B., and Jin, Y. (2000) Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain. Neuron 26:331-343..
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Zhen, M., and Jin, Y. (1999) The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans. Nature 401:371-375..
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Hallam, S.J., and Jin, Y. (1998) lin-14 regulates the timing of synaptic remodelling in Caenorhabditis elegans. Nature 395:78-82..